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Contraindicated (1)pentobarbital will decrease the level or effect of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with potent CYP3A4 inducers may lead to reduced serum concentrations and lack of antimalarial efficacypentobarbital will minimize the level or effect of oxybutynin by affectin